Mastocytes are important immune cells. When stimulated by antigen, chemokines or other immunological cells and mediators, they release their own powerful immune complexes, including histamine, prostaglandins and other vasodilators, which signal to other organs, including the brain. The local blood vessels dilate and other cells move into the area. In turn, these cells activate and pump immune signals around the body. Thus, once a mast cell has degranulated, it is active and firing. It's letting the body know what's going on.

Finally, this is a rhyme I put together a while ago;

Matzoh on Lime

[tick tick tick]
Hassidics walkin', in old J-town,
Faces fixed in a whacked out frown.
Don't be down, just turn it round,
Smile at those men like a circus clown! [elephant trumpets]
Between two nations, that don't eat pork,
A thin, fine line, the snipers walk
Just need to talk (though some men balk)
Been twenty plus years since they fought Norfolk.
But U S A is stuck in Iraq,
Local power they seem to lack.
Take the flack, and bring it back,
Look at Judea, about to crack! [whip sound]

Stop! bouncing bombs up on that line,
Between to nations, who ain't sublime.
We will find peace, we just. need. time.

[tick tick tick]
The middle east, ain't goin well,
anger and tension, they always swell.
When Yasser fell, there tolled a bell,
the holy land won't be turnin' to hell!
Before my airbus, I got full fleece.
Guantanmo captives, they refuse to release.
Now if you please, we must decrease
a soldier's power to police the peace!
Taking meetings, up in the air,
With George and Condy, the new odd-pair,
don't despair, the will is there,
Peaceful solutions and diplomatic flair.

Stop! bouncing bombs up on that line,
Between to nations, who ain't sublime.
We will find peace, we just. need. time.
[tick tick tick]